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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Polydatin, Paclitaxel
Phytochemical Name Polydatin (PubChem CID: 5281718 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 367
Ref_1
Pair Name Polydatin, Paclitaxel
Disease Info [ICD-11: 2B51] Osteosarcoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in S phase
Gene Regulation Up-regulation Expression MKI67 hsa4288
Up-regulation Expression CDKN1A hsa1026
Down-regulation Expression CCNA2 hsa890
Down-regulation Expression CDK2 hsa1017
Down-regulation Expression MMP2 hsa4313
Down-regulation Expression MMP9 hsa4318
Up-regulation Cleavage PARP1 hsa142
Up-regulation Cleavage CASP3 hsa836
Up-regulation Expression ABCB1 hsa5243
Up-regulation Activity AKT1 hsa207
In Vitro Model U2OS Osteosarcoma Homo sapiens (Human) CVCL_0042
MG-63 Osteosarcoma Homo sapiens (Human) CVCL_0426
Result Polydatin may enhance the chemosensitivity of osteosarcoma cells to paclitaxel.
03. Reference
No. Title Href
1 Polydatin enhances the chemosensitivity of osteosarcoma cells to paclitaxel. J Cell Biochem. 2019 Oct;120(10):17481-17490. doi: 10.1002/jcb.29012. Click
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